![]() ![]() Identify the treatment strategies for an alert patient who presents within an hour of overdose versus a patient who presents after two hours.Describe the four clinical stages of acetaminophen toxicity.Review the pathophysiology of acetaminophen toxicity.Single or repeated doses totalling 10-15g or 150 mg/kg of acetaminophen taken within 24 hours may cause severe hepatotoxicity and, less frequently, acute kidney injury (AKI). In Botswana, the highest number of cases of poisoning are caused by acetaminophen if taken in excess of 10-15gms. Key words: Acetaminophen / Paracetamol toxicity, acetaminophen overdose, acute liver failure, N-acetylcysteine, liver hepatotoxicity, hepatic encephalopathy, liver transplant.Īcetaminophen (paracetamol) toxicity is a common medical emergency with serious morbidity and mortality worldwide. ![]() This case report reviews the aetiology, evaluation, and treatment of acetaminophen overdose. ![]() However, studies concerning poisoning in Botswana are scant, although it has been reported that poisoning contributes 6.7% of the total injuries and is ranked third next to falls and automobile accidents among external causes of mortality. Acetaminophen toxicity is the second most common cause of liver transplantation worldwide. It is estimated that poisoning contributes to more than 1 million poisonings and up to half a million deaths each year, yet it is preventable and treatable. South Sudan Medical Journal 2021 14(4):138-141 © 2021 The Author (s) License: This is an open access article under CC BY-NC DOI: Īcetaminophen (paracetamol) toxicity is an important cause of morbidity and mortality worldwide. Submitted: June 2021 Accepted: August 2021 Published: November 2021Ĭitation: Kual, Possible acetaminophen poisoning complicated by puerperal sepsis. Anaesthesiologist, Francistown Academic Hospital, Francistown, BotswanaĬorrespondence: Arop M. ![]()
0 Comments
Leave a Reply. |